tert-Butyl (1-isopropylpiperidin-4-yl)carbamate → 1-(Propan-2-yl)piperidin-4-amine
Reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH:14]([CH3:16])[CH3:15])[CH2:10][CH2:9]1)(C)(C)C>CO.Cl>[CH:14]([N:11]1[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]1)([CH3:16])[CH3:15]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To 4.8 g (1-Isopropyl-piperidin-4-yl)-carbamic acid tert-butyl ester in 15 mL methanol, 20 mL methanolic hydrochloric acid (8 M) were added and the mixture was stirred for 16 h. Removal of the solvent under reduced pressure, followed by removal of residual volatiles by twice coevaporating with toluene, gave the product. Yield: 5.42 g MS (ES+): m/e=143.
Workup
- customRemoval of the solvent under reduced pressure
- customfollowed by removal of residual volatiles
- customgave the product
Sources & evidence
- ORD record
- ord-6fa2e1b0db5b4502a6fba40fd57bed62
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07741341B2
Reaction notes
Loading…