Potassium Carbonate → Piperazin-1-yl(thiazol-2-yl)methanone
Reaction equation
FC(F)(F)C([N:5]1[CH2:10][CH2:9][N:8]([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6]1)=O.C([O-])([O-])=O.[K+].[K+]>CO.O>[N:8]1([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]1Participants
5
Procedure
A solution of compound 7a (3.8 g, 0.013 mol) and K2CO3 (3.5 g, 0.026 mol) in MeOH (40 mL) and water (10 mL), was stirred for 4 h. The solid was collected by filtration and the solvent evaporated in vacuo to give compound 7b (6.12 g). MS m/z (M+H+) 198.1.
Workup
- filtrationThe solid was collected by filtration
- customthe solvent evaporated in vacuo
Sources & evidence
- ORD record
- ord-ed3c0712e86046b0a4a74557c623805a
- Source dataset
- uspto-grants-2015_02
- Patent number
- US08962607B2
Reaction notes
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