Ammonium → tert-Butyl 4-hydroxy-3,3-dimethylpiperidine-1-carboxylate

HRID 185334

Reaction equation

HRID 185334 reaction equation
[BH4-:17].[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][C:10]([CH3:15])([CH3:16])[C:11](=[O:14])[CH2:12][CH2:13]1.[CH3:21][OH:22].[Cl-:19].[NH4+:20].[Na+:18]>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][C:10]([CH3:15])([CH3:16])[CH:11]([OH:14])[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 223AmmoniumHCID 312ChlorideHCID 887MethanolHCID 923Sodium ionHCID 28123BorohydrideHCID 22278899tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

Product 1

HCID 53393265tert-Butyl 4-hydroxy-3,3-dimethylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-81282f0f0d5c4520b6b1b9b7becdcd69
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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