Ethanol → Famciclovir

Reaction equation

[C:1]([CH3:2])(=[O:3])[O:4][CH2:5][CH:6]([CH2:7][CH2:8][n:9]1[c:10]2[n:11][c:12]([NH2:19])[n:13][c:14]([I:18])[c:15]2[n:16][cH:17]1)[CH2:20][O:21][C:22]([CH3:23])=[O:24].[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[CH3:32][CH2:33][OH:34]>>[C:1]([CH3:2])(=[O:3])[O:4][CH2:5][CH:6]([CH2:7][CH2:8][n:9]1[c:10]2[n:11][c:12]([NH2:19])[n:13][cH:14][c:15]2[n:16][cH:17]1)[CH2:20][O:21][C:22]([CH3:23])=[O:24]

Participants

Reactant 3

HCID 702Ethanol

HCID 8471Triethylamine

HCID 15162792[2-(Acetyloxymethyl)-4-(2-amino-6-iodopurin-9-yl)butyl] acetate

Product 1

HCID 3324Famciclovir

Sources & evidence

ORD record: ord-bc628b591d134d63ba4352ba1399e23a
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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