Methanol → N-(4-chlorophenyl)-N'-2-butanesulfonylurea
Reaction equation
[CH3:1][CH:2]([S:5]([NH2:8])(=[O:7])=[O:6])[CH2:3][CH3:4].CO.C[O-].[Na+].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]=[C:22]=[O:23])=[CH:17][CH:16]=1>O1CCCC1>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:8][S:5]([CH:2]([CH2:3][CH3:4])[CH3:1])(=[O:7])=[O:6])=[O:23])=[CH:17][CH:16]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
The method of Example 10 was followed with 2-butanesulfonamide (6.85 g), methanol (250 ml), sodium methoxide (2.7 g), tetrahydrofuran (250 ml) and 4-chlorophenyl isocyanate (7.7 g) with the resulting solid being recrystallized from ethyl acetate to give 2.7 g of white crystals with a melting point of 172-174° C.
Workup
- custombeing recrystallized from ethyl acetate
Sources & evidence
- ORD record
- ord-c50f05fc12104693b6622508876bf68a
- Source dataset
- uspto-grants-2000_11
- Patent number
- US06147115
Reaction notes
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