Hydrochloric Acid → (5-(5-Chlorothiophen-2-yl)isoxazol-3-yl)methanamine

HRID 18579

Reaction equation

HRID 18579 reaction equation
Br[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[S:9][C:10]([Cl:13])=[CH:11][CH:12]=2)[O:5][N:4]=1.C1N2CN3CN(C2)C[N:15]1C3.Cl>CCO>[Cl:13][C:10]1[S:9][C:8]([C:6]2[O:5][N:4]=[C:3]([CH2:2][NH2:15])[CH:7]=2)=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4101HexamethylenetetramineHCID 111501463-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole

Product 1

HCID 68616593(5-(5-Chlorothiophen-2-yl)isoxazol-3-yl)methanamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.00 g (3.59 mmol) 3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole and 503.3 mg (3.59 mmol) urotropin were dissolved in 40 mL EtOH. The reaction mixture was stirred at room temperature for 16 h. The next day 3 mL of a conc. HCl-solution were added and the resulting mixture was refluxed for 45 minutes. After cooling the precipitate was filtered off and washed with water. The white crystalline material was dried under reduced pressure at 40° C.

Workup

  1. temperaturethe resulting mixture was refluxed for 45 minutes
  2. temperatureAfter cooling the precipitate
  3. filtrationwas filtered off
  4. washwashed with water
  5. customThe white crystalline material was dried under reduced pressure at 40° C.

Sources & evidence

ORD record
ord-5a6c7457cfdb4e10b5a9e271bd261c05
Source dataset
uspto-grants-2010_06
Patent number
US07741341B2

Linked notes

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