Sulfuric Acid → N-lauroylvaline isopropyl ester

HRID 1859372

Reaction equation

HRID 1859372 reaction equation
[C:1]([NH:14][C@H:15]([C:19]([OH:21])=[O:20])[CH:16]([CH3:18])[CH3:17])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].S(=O)(=O)(O)O.[CH:27](O)([CH3:29])[CH3:28]>>[CH:27]([O:20][C:19](=[O:21])[C@H:15]([CH:16]([CH3:18])[CH3:17])[NH:14][C:1](=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])([CH3:29])[CH3:28]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 26658N-(1-Oxododecyl)-L-valine

Product 1

HCID 54560200N-lauroylvaline isopropyl ester

Procedure

Forty-nine(49) grams of N-lauroylvaline and 197 g of isopropanol were charged into a 500-milliliter flask. Further, 1.61 g of conc. sulfuric acid were added as the catalyst. The mixture was heated under reflux for reaction for 6 hours.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for reaction for 6 hours

Sources & evidence

ORD record
ord-e9c9d541e8334afbbb2a662a6a674734
Source dataset
uspto-grants-2003_03
Patent number
US06528068B1

Linked notes

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