Dichloromethane → 3-chloro-2,2-dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]-N-(naphthalen-2-ylmethyl)propanamide

HRID 186074

Reaction equation

HRID 186074 reaction equation
[CH3:1][N:2]1[C:3](=[O:32])[NH:4][C:5](=[O:31])[C:6]12[CH2:7][c:8]1[cH:9][cH:10][c:11]([NH:15][C:16]([CH2:17][NH:18][CH2:19][c:20]3[cH:21][c:22]4[cH:23][cH:24][cH:25][cH:26][c:27]4[cH:28][cH:29]3)=[O:30])[cH:12][c:13]1[CH2:14]2.[CH3:41][CH2:42][N:43]([CH2:44][CH3:45])[CH2:46][CH3:47].[Cl:33][CH2:34][C:35]([C:36](=[O:37])[Cl:38])([CH3:39])[CH3:40].[Cl:48][CH2:49][Cl:50]>>[CH3:1][N:2]1[C:3](=[O:32])[NH:4][C:5](=[O:31])[C:6]12[CH2:7][c:8]1[cH:9][cH:10][c:11]([NH:15][C:16]([CH2:17][N:18]([CH2:19][c:20]3[cH:21][c:22]4[cH:23][cH:24][cH:25][cH:26][c:27]4[cH:28][cH:29]3)[C:36]([C:35]([CH2:34][Cl:33])([CH3:39])[CH3:40])=[O:37])=[O:30])[cH:12][c:13]1[CH2:14]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 613453-Chloro-2,2-dimethylpropanoyl chlorideHCID 178481630N-(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)-2-(naphthalen-2-ylmethylamino)acetamide

Product 1

HCID 723316823-chloro-2,2-dimethyl-N-[2-[(1'-methyl-2',4'-dioxospiro[1,3-dihydroindene-2,5'-imidazolidine]-5-yl)amino]-2-oxoethyl]-N-(naphthalen-2-ylmethyl)propanamide

Sources & evidence

ORD record
ord-fdc0faba46ff441fa10a31a7c3fe6c0c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

Loading…