Pamidronic Acid → Pamidronate Disodium Anhydrous

HRID 1862082

Reaction equation

HRID 1862082 reaction equation
[CH2:1]([C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5])[CH2:2][NH2:3].[OH-].[Na+:15]>>[CH2:1]([C:4]([P:10]([O-:13])([OH:12])=[O:11])([P:6]([O-:8])([OH:9])=[O:7])[OH:5])[CH2:2][NH2:3].[Na+:15].[Na+:15]

Participants

3

Reactant 2

HCID 4674Pamidronic AcidHCID 14798Sodium Hydroxide

Product 1

HCID 73351Pamidronate Disodium AnhydrousYield 94%

Conditions

Temperature
0 °C

Procedure

Pamidronic acid (50 g) is dissolved in hot sodium hydroxide solution (150 ml) of 12.5% p/v (parts/volume) at 90° C. and the mixture was adjusted to pH 7.5˜8.5. By filtering the solution, the insoluble material is removed. The filtrate is added to isopropanol (400 ml) which is stirring. After the mixture is cooled to 0° C. filtered and dried in oven at 90° C. white disodium pamidronate (55.8 g. yield 94%) is obtained.

Workup

  1. filtrationBy filtering the solution
  2. customthe insoluble material is removed
  3. additionThe filtrate is added to isopropanol (400 ml) which
  4. filtrationfiltered

Sources & evidence

ORD record
ord-107b5b9bbd164c75add5da1a963871cf
Source dataset
uspto-grants-2003_03
Patent number
US06534674B2

Linked notes

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