HCID 18619274, compound → HCID 18619216, compound
Reaction equation
C([O:8][C:9]1[C:10]([O:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])=[N:11][CH:12]=[N:13][CH:14]=1)C1C=CC=CC=1>[Pd].C(OCC)(=O)C>[OH:8][C:9]1[C:10]([O:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])=[N:11][CH:12]=[N:13][CH:14]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 0.9 g of 5-benzyloxy-4-(methoxycarbonyl)methoxypyrimidine, 10% palladium/carbon and ethyl acetate was stirred for 3 hours at room temperature under hydrogen atmosphere. The reaction system was purged with nitrogen, then, the reaction solution was filtrated through Celite, and the filtrate was concentrated to obtain 0.574 g of 5-hydroxy-4-(methoxycarbonyl)methoxypyrimidine.
Workup
- customThe reaction system was purged with nitrogen
- filtrationthe reaction solution was filtrated through Celite
- concentrationthe filtrate was concentrated
Sources & evidence
- ORD record
- ord-58ebe2121bf243a9ad3a7de95fb5fff0
- Source dataset
- uspto-grants-2003_03
- Patent number
- US06537948B1
Reaction notes
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