Water → methyl 4-(2-tert-butoxy-2-oxoethyl)tetrahydro-2H-pyran-4-carboxylate

HRID 186329

Reaction equation

HRID 186329 reaction equation
[Br:23][CH2:24][C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31].[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[O:13]1[CH2:14][CH2:15][CH:16]([C:19](=[O:20])[O:21][CH3:22])[CH2:17][CH2:18]1.[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1.[OH2:37]>>[O:13]1[CH2:14][CH2:15][C:16]([C:19](=[O:20])[O:21][CH3:22])([CH2:24][C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:17][CH2:18]1

Participants

7

Reactant 6

HCID 962WaterHCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 79177tert-Butyl bromoacetateHCID 27735202H-Pyran-4-carboxylic acid, tetrahydro-, methyl esterHCID 178418339Butyllithium

Product 1

HCID 21985691methyl 4-(2-tert-butoxy-2-oxoethyl)tetrahydro-2H-pyran-4-carboxylate

Sources & evidence

ORD record
ord-6805a39032044c178bb716a45a8c99ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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