Hydrochloric Acid → HCID 68523413, compound
Reaction equation
[O:1]=[C:2]1[C:7]2[N:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[N:10]=[CH:11][C:6]=2[CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.Cl>O1CCOCC1>[F:15][C:12]([F:13])([F:14])[C:9]1[N:10]=[CH:11][C:6]2[CH2:5][CH2:4][NH:3][C:2](=[O:1])[C:7]=2[N:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Approximately 485 mg (1.53 mmol) of tert-butyl 8-oxo-2-(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate was treated with 10 mL of 4M HCl in anhydrous dioxane, and the solution was stirred at room temperature for 0.5 h, then concentrated to dryness. The residue was washed with diethyl ether and dried to give the title compound as a white solid. LC-MS 218 (M+1).
Workup
- concentrationconcentrated to dryness
- washThe residue was washed with diethyl ether
- customdried
Sources & evidence
- ORD record
- ord-03cd092c21e3479c8be45433c6e5e74e
- Source dataset
- uspto-grants-2009_12
- Patent number
- US07625888B2
Reaction notes
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