Hydrochloric Acid → Methyl((oxan-4-yl)methyl)amine hydrochloride
Reaction equation
C(O[C:6](=O)[N:7](C)[CH2:8][CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)(C)(C)C.[ClH:17]>O1CCOCC1>[ClH:17].[CH3:6][NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of N-methyl-N-(tetrahydro-pyran-4-ylmethyl)-carbamic acid tert-butyl ester (740 mg) in 4N hydrochloric acid in 1,4-dioxan (10 ml, ex Aldrich) was stirred at room temperature for 1 h. The dioxan was removed under reduced pressure and the residue triturated with ether. The solid was filtered onto a sinter, washed with ether and dried, to afford N-methyl-N-(tetrahydro-pyran-4-ylmethyl)-amine hydrochloride (460 mg).
Workup
- customThe dioxan was removed under reduced pressure
- customthe residue triturated with ether
- filtrationThe solid was filtered onto a sinter
- washwashed with ether
- customdried
Sources & evidence
- ORD record
- ord-13c521263bec42b8bdb2804d08be11b8
- Source dataset
- uspto-grants-2009_12
- Patent number
- US07635701B2
Reaction notes
Loading…