Tetrahydrofuran → 4-Methoxy-but-2-enoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide

HRID 186981Notes

Reaction equation

HRID 186981 reaction equation
[Br:1][c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][cH:11][n:12][c:13]3[cH:14][cH:15][c:16]([NH2:19])[cH:17][c:18]23)[cH:5][cH:6][cH:7]1.[CH3:28][O:29][CH2:30][CH:31]=[CH:32][C:33](=[O:34])[Cl:35].[CH:20]([N:21]([CH:22]([CH3:23])[CH3:24])[CH3:25])([CH3:26])[CH3:27].[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1>>[Br:1][c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][cH:11][n:12][c:13]3[cH:14][cH:15][c:16]([NH:19][C:33]([CH:32]=[CH:31][CH2:30][O:29][CH3:28])=[O:34])[cH:17][c:18]23)[cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 547370N,N-DiisopropylmethylamineHCID 5328042N4-(3-Bromophenyl)quinazoline-4,6-diamineHCID 544294024-Methoxybut-2-enoyl chloride

Product 1

HCID 543919464-Methoxy-but-2-enoic acid [4-(3-bromo-phenylamino)-quinazolin-6-yl]-amide

Sources & evidence

ORD record
ord-a3554ef0c171441b80af22837e7f877c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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