Methyl iodide → 3-methyl-2H-1,3-oxazine-2,6(3H)-dione
Reaction equation
[O:1]1[C:6](=[O:7])[CH:5]=[CH:4][NH:3][C:2]1=[O:8].[C:9](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:9][N:3]1[CH:4]=[CH:5][C:6](=[O:7])[O:1][C:2]1=[O:8]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
At room temperature, 1.50 g of 2H-1,3-oxazine-2,6(3H)-dione, 2.19 g of potassium carbonate and 3.77 g of methyl iodide were sequentially added to 30 ml of acetone, and the mixture was stirred for 10 hours under heat refluxing condition. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure, and the resulting solid was dried to obtain 1.46 g of 3-methyl-2H-1,3-oxazine-2,6(3H)-dione represented by the formula:
Workup
- temperatureunder heat
- temperaturerefluxing condition
- filtrationfiltered
- concentrationThe filtrate was concentrated under reduced pressure
- customthe resulting solid was dried
Sources & evidence
- ORD record
- ord-36ef244875b741e89bf195fc32c3bf95
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08304437B2
Reaction notes
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