Hydrochloric Acid → 3-(6-Bromopyridin-3-yl)prop-2-enoic acid
Reaction equation
C[O:2][C:3](=[O:13])[CH:4]=[CH:5][C:6]1[CH:7]=[N:8][C:9]([Br:12])=[CH:10][CH:11]=1.[OH-].[Na+].O.Cl>O1CCOCC1>[Br:12][C:9]1[N:8]=[CH:7][C:6]([CH:5]=[CH:4][C:3]([OH:13])=[O:2])=[CH:11][CH:10]=1Participants
6
Procedure
750 mg (3.1 mmol) of 3-(6-bromo-pyridin-3-yl)-acrylic acid methyl ester was dissolved in 30 ml of dioxane and 4.65 ml of a 2 N aqueous sodium hydroxide solution was added. The reaction mixture was stirred at room temperature for 2 h. The reaction solution was poured into water and acidified with concentrated hydrochloric acid, whereupon the product precipitated. The product was isolated by filtration and dried under reduced pressure. Yield: 673 mg.
Workup
- customprecipitated
- customThe product was isolated by filtration
- customdried under reduced pressure
Sources & evidence
- ORD record
- ord-679c8d006cc14ad783dceebdc9462637
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08304438B2
Reaction notes
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