Sodium Sulfate → 2-(2-Aminopropyl)thiophene
Reaction equation
[N+:1]([C:4]([CH3:11])=[CH:5][C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)([O-])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].S([O-])([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[CH3:11][CH:4]([NH2:1])[CH2:5][C:6]1[S:7][CH:8]=[CH:9][CH:10]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3.7 g (21.9 mmol) 2-(2-nitro-propenyl)-thiophene in 50 ml THF is added dropwise to a suspension of 4.1 g (109.3 mmol) lithium aluminium hydride in 150 ml THF. After the addition has ended the mixture is refluxed. After 1.5 hours it is cooled to RT and stirred for another 16 hours. Then the mixture is slowly combined with 10 ml sat. sodium sulphate solution and filtered through Celite. The filtrate thus obtained is evaporated down i. vac.
Workup
- additionAfter the addition
- temperatureis refluxed
- filtrationfiltered through Celite
- customThe filtrate thus obtained
- customis evaporated down i
Sources & evidence
- ORD record
- ord-5dccfa5efd51411fbe1ff5834ec936bc
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08309542B2
Reaction notes
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