Ammonia → 6-(4-Chloro-1H-imidazol-1-yl)-4-pyrimidinamine
Reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH:12]=[C:11]([Cl:13])[N:10]=[CH:9]2)[N:5]=[CH:4][N:3]=1.[NH3:14]>C(O)(C)C>[Cl:13][C:11]1[N:10]=[CH:9][N:8]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([NH2:14])[CH:7]=2)[CH:12]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 4-chloro-6-(4-chloro-1H-imidazol-1-yl)pyrimidine (0.99 g, 4.60 mmol) in 2 M ammonia (20 mL, 40.0 mmol)/isopropanol was heated at 80° C. in a sealed vial for 18 h. After cooling the solid precipitate was filtered and dried to give 6-(4-chloro-1H-imidazol-1-yl)pyrimidin-4-amine (884 mg, 98% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 8.44 (1H, d, J=1.51 Hz), 8.32 (1H, d, J=0.76 Hz), 7.96 (1H, d, J=1.51 Hz), 7.30 (2H, br. s.), 6.58 (1H, d, J=1.01 Hz). LCMS: RT=0.57 min, MH+=196.1.
Workup
- temperatureAfter cooling the solid precipitate
- filtrationwas filtered
- customdried
Sources & evidence
- ORD record
- ord-10c75d0465b249a097deb98ce985e784
- Source dataset
- uspto-grants-2012_11
- Patent number
- US08309577B2
Reaction notes
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