Tetrahydrofuran → tert-Butyl 4-(2-fluorophenyl)-4-hydroxypiperidine-1-carboxylate
Reaction equation
[Br:1][c:2]1[c:3]([F:8])[cH:4][cH:5][cH:6][cH:7]1.[C:14]([CH3:15])([CH3:16])([CH3:17])[O:18][C:19](=[O:20])[N:21]1[CH2:22][CH2:23][C:24](=[O:27])[CH2:25][CH2:26]1.[CH2:9]([Li:10])[CH2:11][CH2:12][CH3:13].[O:28]1[CH2:29][CH2:30][CH2:31][CH2:32]1>>[c:2]1([C:24]2([OH:27])[CH2:23][CH2:22][N:21]([C:19]([O:18][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:20])[CH2:26][CH2:25]2)[c:3]([F:8])[cH:4][cH:5][cH:6][cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-dc7d7873f5c648f3aaa6cf18d2c8bfc9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
Loading…