Carbon Dioxide → Creatine Monohydrate

HRID 1883233Notes

Reaction equation

HRID 1883233 reaction equation
[NH:1]([CH2:3][C:4]([O-:6])=[O:5])[CH3:2].[Na+].C(=O)=O.[N:11]#[C:12][NH2:13]>>[OH2:5].[O:5]=[C:4]([CH2:3][N:1]([C:12](=[NH:11])[NH2:13])[CH3:2])[OH:6]

Participants

4

Reactant 3

HCID 280Carbon Dioxide2×HCID 9864Cyanamide2×HCID 23667259Sodium Sarcosinate

Product 1

HCID 80116Creatine Monohydrate

Conditions

Temperature
75 °C

Procedure

1315 g of a 40% strength aqueous sodium sarcosinate solution (pH 14) were introduced into a 2 1 three-necked flask having a mechanical stirrer, heating bath, reflux condenser and gas inlet tube and the mixture was adjusted to pH 9 by introduction of carbon dioxide gas. After heating the solution to 75° C., 338 g of a 50% strength aqueous cyanamide solution were added in the course of 4 hours. The temperature was kept constant at 75° C. during the entire addition period. The pH remained between 9 and 10 without introduction of further CO2 gas. After the addition of cyanamide, the reaction solution was stirred for 2 hours and then cooled to 35° C. The precipitated creatine was filtered off, washed with water and dried. 480 g of creatine monohydrate having a crystal yield of 75% were obtained.

Workup

  1. temperatureheating bath
  2. temperaturereflux condenser and gas inlet tube
  3. additionThe temperature was kept constant at 75° C. during the entire addition period
  4. temperaturecooled to 35° C
  5. filtrationThe precipitated creatine was filtered off
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-14ba6a5637474b20a0078717fb1044af
Source dataset
uspto-grants-2004_07
Patent number
US06759553B1

Reaction notes

Loading…