Ammonium formate → 3-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine
Reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([N:13]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:14][CH2:15][F:16])[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd]>[C:17]([N:13]([CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[CH2:14][CH2:15][F:16])([O:19][C:20]([CH3:22])([CH3:23])[CH3:21])=[O:18]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A 225 mg sample of the compound from step 448a was treated with ammonium formate and 10% Pd/C according to the procedure of step 445b for 1 hour, and the title compound was isolated (190 mg).
Sources & evidence
- ORD record
- ord-e4fd5c455c0c484e90968bd95fad35ab
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05726182
Reaction notes
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