Ammonium formate → 3-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine

HRID 1885

Reaction equation

HRID 1885 reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([N:13]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:14][CH2:15][F:16])[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd]>[C:17]([N:13]([CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[CH2:14][CH2:15][F:16])([O:19][C:20]([CH3:22])([CH3:23])[CH3:21])=[O:18]

Participants

4

Reactant 2

HCID 2723923Ammonium formateHCID 196914211-benzyl-3-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine

Product 1

HCID 196914543-(N-BOC-N-(2-fluoroethyl)amino)pyrrolidine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A 225 mg sample of the compound from step 448a was treated with ammonium formate and 10% Pd/C according to the procedure of step 445b for 1 hour, and the title compound was isolated (190 mg).

Sources & evidence

ORD record
ord-e4fd5c455c0c484e90968bd95fad35ab
Source dataset
uspto-grants-1998_03
Patent number
US05726182

Linked notes

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