Trifluoroacetic acid → HCID 178481704, compound

HRID 1886003

Reaction equation

HRID 1886003 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3](O)=O.[CH3:8][NH:9][C:10](=[S:13])[NH:11][NH2:12].FC(F)(F)C(F)=O>>[F:1][C:2]([F:7])([F:6])[C:3]1[N:9]([CH3:8])[C:10]([SH:13])=[N:11][N:12]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 67716Trifluoroacetyl fluorideHCID 2723853N-Methylhydrazinecarbothioamide

Product 1

HCID 178481704HCID 178481704, compound

Procedure

This exemplified compound may be readily synthesized by the reaction of methyl isocyanate with hydrazine to give 4-methyl-3-thiosemicarbazide followed by cyclocondensation with trifluoroacetic acid as described in U.S. Pat. No. 4,477,459. This compound may also be prepared by the reaction of 4-methyl-3-thiosemicarbazide with trifluoroacetylfluoride and heat (U.S. Pat. No. 3,780,052).

Workup

  1. temperatureheat (U.S

Sources & evidence

ORD record
ord-b98c545d21194b3c89942f661b4ae0d1
Source dataset
uspto-grants-1992_09
Patent number
US05149620

Linked notes

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