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Hydrochloric Acid → HCID 68412886, compound

HRID 1887759
Notes
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Reaction equation

HRID 1887759 reaction equation
[NH2:1][C:2]([CH3:45])([CH3:44])[C:3]([NH:5][C@H:6]([CH2:33][C:34]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[N:36]([CH3:43])[CH:35]=1)[C:7](=[O:32])[NH:8][CH:9]1[CH2:18][C:17]2[C:12](=[C:13]([N:19]3[CH2:23][CH2:22][CH2:21][C:20]3=[O:24])[CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:25][C:26]2[CH:30]=[CH:29][S:28][CH:27]=2)[C:10]1=[O:31])=[O:4].[ClH:46]>C(O)C>[ClH:46].[NH2:1][C:2]([CH3:45])([CH3:44])[C:3]([NH:5][C@H:6]([CH2:33][C:34]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[N:36]([CH3:43])[CH:35]=1)[C:7](=[O:32])[NH:8][CH:9]1[CH2:18][C:17]2[C:12](=[C:13]([N:19]3[CH2:23][CH2:22][CH2:21][C:20]3=[O:24])[CH:14]=[CH:15][CH:16]=2)[N:11]([CH2:25][C:26]2[CH:30]=[CH:29][S:28][CH:27]=2)[C:10]1=[O:31])=[O:4]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59620360HCID 59620360, compound

Product 1

HCID 68412886HCID 68412886, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Amino-2-methyl-N-[(2R)-3-(1-methyl-1H-indol-3-yl)-1-oxo-1-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-ylamino]propan-2-yl]propanamide (116 mg) was dissolved in ethanol (1.0 mL), and 1N hydrochloric acid (161 μL) was added thereto. Subsequently, the solvent was evaporated under reduced pressure, whereby the title compound (103 mg) was yielded.

Workup

  1. customSubsequently, the solvent was evaporated under reduced pressure, whereby the title compound (103 mg)
  2. customwas yielded

Sources & evidence

ORD record
ord-29324d5e1a664ad0bf2a09916d38cfd1
Source dataset
uspto-grants-2013_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08501772B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes