Hydrazine hydrate (1:1) → 2-Oxo-1,2-dihydropyridine-3-carbohydrazide
Reaction equation
O.[NH2:2][NH2:3].[OH:4][C:5]1[C:10]([C:11]([O:13]C)=O)=[CH:9][CH:8]=[CH:7][N:6]=1>C(O)C>[O:4]=[C:5]1[C:10]([C:11]([NH:2][NH2:3])=[O:13])=[CH:9][CH:8]=[CH:7][NH:6]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Hydrazine hydrate (0.192 mL, 3.92 mmol) was added to a solution of the methyl 2-hydroxy-3-pyridinecarboxylate (400 mg, 2.61 mmol, commercially available from e.g. Apollo or Butt Park) in ethanol (10 mL) and the reaction was heated to reflux for 16 hrs. The reaction was cooled and the solvent was evaporated to afford an off-white solid in 395 mg.
Workup
- temperatureto reflux for 16 hrs
- temperatureThe reaction was cooled
- customthe solvent was evaporated
- customto afford an off-white solid in 395 mg
Sources & evidence
- ORD record
- ord-031795ea8d9744fd811b0b87a5eebc37
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08501946B2
Reaction notes
Loading…