Hydrazine hydrate (1:1) → HCID 178428523, compound
Reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[N:3]=1.O.[NH2:11][NH2:12]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8](=[NH:9])[NH:11][NH2:12])[N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-methyl-2-pyrimidinecarbonitrile (I98)(0.190 g, 1.595 mmol) was dissolved in ethanol (3.19 ml) and hydrazine hydrate (0.100 ml, 3.19 mmol) was added. The reaction mixture was left at reflux for 2.5 hours. TLC showed that no starting material remained so the solvent was removed under reduced pressure to afford the crude desired product in 247 mg.
Workup
- waitThe reaction mixture was left
- temperatureat reflux for 2.5 hours
- customwas removed under reduced pressure
Sources & evidence
- ORD record
- ord-1e337ac954234acbb6d2f95036a7e422
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08501946B2
Reaction notes
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