Ammonium Hydroxide → 9-Aminononanoic acid

HRID 1889150Notes

Reaction equation

Br[CH:2](C)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11].[OH-].[NH4+:15]>>[NH2:15][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11]

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 46849969-Bromo-decanoic acid

Product 1

HCID 1368779-Aminononanoic acid

Procedure

9-bromodecanoic acid (2.0052 gr, 8.46 mmol) was added to a round bottom flask containing 80 mL of aqueous ammonium hydroxide (25% NH3). The resulting mixture was stirred for 24 hours at room temperature, after which the aqueous solution was evaporated under reduced pressure, resulting in product 8a as a white solid at quantitative yield. 1H-NMR (200 MHz, CD3OD): 1.25-1.4 (m; 8H), 1.5-1.7 (m; 4H), 2.23 (t; J=7.31 Hz; 2H), 2.87 (t; J=7.45 Hz; 2H).

Workup

customafter which the aqueous solution was evaporated under reduced pressure

Sources & evidence

ORD record: ord-fea56029035e4fc1b7b74a0469a11682
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501969B2

Reaction notes

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