1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 1889295

Reaction equation

HRID 1889295 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([OH:14])=[O:13].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([OH:1])=[C:3]([C:12]([OH:14])=[O:13])[CH:4]=1

Participants

4

Reactant 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 24408Bromine

Product 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To a solution of 2.50 g 1-hydroxy-2-naphthoic acid in 50 ml chloroform a solution of 0.68 ml bromine in 5 ml chloroform was added dropwise. After 16 h the reaction was concentrated to yield 3.40 g 4-bromo-1-hydroxy-naphthalene-2-carboxylic acid.

Workup

  1. concentrationAfter 16 h the reaction was concentrated

Sources & evidence

ORD record
ord-c476824724194ed09ca48b85851eeef4
Source dataset
uspto-grants-2013_08
Patent number
US08501981B2

Linked notes

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