4-Phenylcyclohexanone → [1-(4-Phenyl-cyclohexyl)-azetidin-3-yl]-carbamic acid tert-butyl ester

HRID 1893299

Reaction equation

[C:1]1([CH:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:14]([O:18][C:19](=[O:25])[NH:20][CH:21]1[CH2:24][NH:23][CH2:22]1)([CH3:17])([CH3:16])[CH3:15]>>[C:14]([O:18][C:19](=[O:25])[NH:20][CH:21]1[CH2:24][N:23]([CH:10]2[CH2:11][CH2:12][CH:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:8][CH2:9]2)[CH2:22]1)([CH3:17])([CH3:15])[CH3:16]

Participants

Reactant 2

HCID 786054-Phenylcyclohexanone

HCID 15194053-Aminoazetidine, 3-BOC protected

Product 1

HCID 59541918[1-(4-Phenyl-cyclohexyl)-azetidin-3-yl]-carbamic acid tert-butyl ester

Procedure

The title compound was prepared as a white solid by reductive amination of 4-phenyl-cyclohexanone and azetidin-3-yl-carbamic acid tert-butyl ester using the procedure described in Step D of Example 1.

Sources & evidence

ORD record: ord-fa4d51a67a91493a9541ce32c23f384f
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08513229B2

Linked notes

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