Dimethylformamide dimethyl acetal → (3E)-1-(3-bromophenyl)-3-(dimethylaminomethylidene)thiourea
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([NH2:11])=[S:10])[CH:5]=[CH:6][CH:7]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CCOCC>[Br:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](/[N:11]=[CH:14]/[N:15]([CH3:17])[CH3:16])=[S:10])[CH:5]=[CH:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
(3-Bromophenyl)thiourea (2.1 g, 9.1 mmol) was suspended in N,N-dimethylformamide dimethyl acetal and was heated to 100° C. for 2 d. The cooled mixture was diluted with ether and filtered and the solid washed with ether to give the title compound (2.42 g).
Workup
- filtrationfiltered
- washthe solid washed with ether
Sources & evidence
- ORD record
- ord-6a3488b0d32d424b9a0bff0e440f677e
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08513276B2
Reaction notes
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