Hydrochloric Acid → PRAMIPEXOLE HCl

HRID 1895895

Reaction equation

HRID 1895895 reaction equation
[CH3:1][CH2:2][CH2:3][NH:4][C@@H:5]1[CH2:14][C:9]2[S:10][C:11]([NH2:13])=[N:12][C:8]=2[CH2:7][CH2:6]1.[ClH:15]>C(OC(C)C)(=O)C>[CH3:1][CH2:2][CH2:3][NH:4][C@@H:5]1[CH2:14][C:9]2[S:10][C:11]([NH2:13])=[N:12][C:8]=2[CH2:7][CH2:6]1.[ClH:15]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 119570Pramipexole2×

Product 1

HCID 9964861PRAMIPEXOLE HCl

Reagents, catalysts & solvents 1

HCID 7915Isopropyl AcetateSolvent2×

Conditions

Temperature
15 °C

Procedure

An alternate method for conversion of the sulfonate or halide salts of pramipexole to an HCl salt involves the use of a concentrated solution of HCl and isopropyl acetate (IPAC). A sulfonate or halide salt of pramipexole may be taken up in IPAC and cooled to 15° C. HCl (gas) may be bubbled into the slurry for about 1 hour, after which the mixture may be filtered, washed with IPAC and dried under vacuum at room temperature to afford a pramipexole dihydrochloride salt. A detailed example of this synthesis may be found in Example 9.

Workup

  1. customHCl (gas) may be bubbled into the slurry for about 1 hour
  2. filtrationafter which the mixture may be filtered
  3. washwashed with IPAC
  4. customdried under vacuum at room temperature

Sources & evidence

ORD record
ord-1d67fdf5a9774c2794f3e3dc138949ed
Source dataset
uspto-grants-2013_08
Patent number
US08518926B2

Linked notes

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