Hydrazine hydrate (1:1) → HCID 22174882, compound
Reaction equation
CS[C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:6]=[CH:5][N:4]=1.O.[NH2:16][NH2:17]>C(O)C>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:7]1[N:6]=[CH:5][N:4]=[C:3]([NH:16][NH2:17])[N:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A stirred solution of the product of step 2 (0.763 g, 3.74 mmol) and hydrazine hydrate (0.22 mL, 3.9 mmol) in ethanol (8 mL) was heated at reflux for 30 minutes. The reaction was cooled in an ice bath and the precipitate was filtered off. Vacuum oven drying afforded crude product as light brown solid. This material was used without further purification in the next step.
Workup
- temperatureat reflux for 30 minutes
- temperatureThe reaction was cooled in an ice bath
- filtrationthe precipitate was filtered off
- customVacuum oven drying
- customafforded crude product as light brown solid
- customThis material was used without further purification in the next step
Sources & evidence
- ORD record
- ord-c4ecbb6ddbbf4494a2d073d5fccf490a
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08518999B2
Reaction notes
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