Hydrogen iodide → HCID 178506554, compound
Reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[N:10][C:3]=12.[IH:11]>>[I:11][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[N:10][C:3]=12Participants
3
Procedure
A mixture of 7-chloro-3H-imidazo[4,5-b]pyridine (1.47 g, 9.64 mmol) and 15 mL of 57% hydriodic acid were reacted at 80° C. for 4 h. After the solid was filtered off it was resubmitted to the reaction with 10 mL of fresh 57% hydriodic acid. The reaction yielded 1.3 g of the product as a black powder, 90% pure.
Workup
- customwere reacted at 80° C. for 4 h
- filtrationAfter the solid was filtered off it
- customwas resubmitted to the reaction with 10 mL of fresh 57% hydriodic acid
Sources & evidence
- ORD record
- ord-aa8a22b4106347ec917b9abc2089866a
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08519135B2
Reaction notes
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