Thiophosgene → 2-Chloro-4-methylphenyl isothiocyanate

HRID 1898301

Reaction equation

HRID 1898301 reaction equation
[Cl:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:10](Cl)(Cl)=[S:11].C(N(C(C)C)C(C)C)C>>[Cl:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:3]=1[N:4]=[C:10]=[S:11]

Participants

4

Reactant 3

HCID 10040ThiophosgeneHCID 120072-Chloro-p-toluidineHCID 81531Diisopropylethylamine

Product 1

HCID 1435292-Chloro-4-methylphenyl isothiocyanateYield 58.3%

Procedure

The title compound was prepared following the procedure described for intermediate-2 using 2-chloro-4-methyl aniline (2.0 g, 14.00 mmol), thiophosgene (1.62 g, 14.00 mmol) and N-ethyl di-isopropyl amine (3.63 g, 28.00 mmol) to afford 1.5 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-3b59b75f740b42dfa65e357b2132c9af
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Linked notes

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