Water → 2-(Propan-2-yl)benzene-1-sulfonyl fluoride

HRID 1899010

Reaction equation

HRID 1899010 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10](Cl)(=[O:12])=[O:11])([CH3:3])[CH3:2].[F-:14].[K+].O>O1CCOCC1>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10]([F:14])(=[O:12])=[O:11])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 962Water2×HCID 522689Potassium FluorideHCID 129164822-(Propan-2-yl)benzene-1-sulfonyl chloride

Product 1

HCID 233731302-(Propan-2-yl)benzene-1-sulfonyl fluorideYield 96.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

27 g of 2-isopropylbenzenesulfonyl chloride and 22 g of KF are stirred in 75 ml of dioxane and 20 ml of water at 45° C. for 27 h and at RT for 45 h. 800 ml of water are then added, and the mixture is extracted with 3×300 ml of EA. The combined organic phases are dried over Na2SO4 and the solvent is removed in vacuo. 24 g of a colorless oil are obtained.

Workup

  1. extractionthe mixture is extracted with 3×300 ml of EA
  2. dry with materialThe combined organic phases are dried over Na2SO4
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-f3291efbbab14b2a9a7fef2bd49b44d7
Source dataset
uspto-grants-1996_11
Patent number
US05571842

Linked notes

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