Morpholine → Chloromethyl 4-morpholinecarboxylate
Reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]([O:10][CH2:11][Cl:12])=[O:9]>C(Cl)Cl>[N:1]1([C:8]([O:10][CH2:11][Cl:12])=[O:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Morpholine (1 equiv.) is slowly added to a 0.1M solution of chloromethyl chloroformate (10 equiv.) in methylene chloride at low temperature. After 15 min at low temperature and a suitable time at 25° C. the reaction mixture is filtered and concentrated to dryness under reduced pressure. The residue is purified by flash chromatography giving chloromethyl morpholine-4-carboxylate.
Workup
- filtrationa suitable time at 25° C. the reaction mixture is filtered
- concentrationconcentrated to dryness under reduced pressure
- customThe residue is purified by flash chromatography
Sources & evidence
- ORD record
- ord-749605c877ab4c14aee248009df64e67
- Source dataset
- uspto-grants-1996_11
- Patent number
- US05574097
Reaction notes
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