N-Methylheptylamine → 1-(4-Fluoro-2-nitrophenyl)-3-heptyl-3-methylurea

HRID 1901059

Reaction equation

HRID 1901059 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:17])OC2C=CC=CC=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.[CH3:21][NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>C1(C)C(C)=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([N:22]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH3:21])=[O:17])=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1

Participants

4

Reactant 2

HCID 93190N-MethylheptylamineHCID 23370075Phenyl 4-fluoro-2-nitrophenylcarbamate

Product 1

HCID 233701111-(4-Fluoro-2-nitrophenyl)-3-heptyl-3-methylurea

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Phenyl 4-fluoro-2-nitrophenylcarbamate (0.70 g) and N-methylheptylamine (0.33 g) were dissolved in xylene (5 ml) and the solution was heated under reflux for 2 hrs. The solvent was distilled off and the residue was purified by a silica gel column chromatography (hexane:ethyl acetate=3:1) to give 1-(4-fluoro-2-nitrophenyl)-3-heptyl-3-methylurea as an oily product.

Workup

  1. temperaturethe solution was heated
  2. temperatureunder reflux for 2 hrs
  3. distillationThe solvent was distilled off
  4. customthe residue was purified by a silica gel column chromatography (hexane:ethyl acetate=3:1)

Sources & evidence

ORD record
ord-0ed557f86cb647dda8e553acb0bf24a6
Source dataset
uspto-grants-1996_11
Patent number
US05576335

Linked notes

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