Hydrogen Bromide → (R)-2-Amino-4-(4-hydroxyphenyl)butanoic acid hydrobromide
Reaction equation
COC([NH:5][C@H:6]([CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[CH:14][CH:13]=1)[C:7]([OH:9])=[O:8])=O.[BrH:20]>C(O)(=O)C>[BrH:20].[OH:18][C:15]1[CH:14]=[CH:13][C:12]([CH2:11][CH2:10][C@@H:6]([NH2:5])[C:7]([OH:9])=[O:8])=[CH:17][CH:16]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of (2R)-2-[(methoxycarbonyl)amino]-4-(4-methoxyphenyl)-butanoic acid (5.0 g, 18.7 mmol) in 5 mL of 30% HBr in acetic acid was heated at 60° C. overnight. The reaction mixture was cooled to room temperature and the solvent was removed under reduced pressure to give the title compound as an orange solid.
Workup
- customthe solvent was removed under reduced pressure
Sources & evidence
- ORD record
- ord-cd495096f60c472b8b6e9f5ce78a2d6a
- Source dataset
- uspto-grants-1996_11
- Patent number
- US05578593
Reaction notes
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