Piperidine → 1-(Piperidin-1-yl)dodecan-1-one

Reaction equation

[C:1](Cl)(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[C:1]([N:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

Reactant 2

HCID 8082Piperidine

HCID 8166Dodecanoyl chloride

Product 1

HCID 2468111-(Piperidin-1-yl)dodecan-1-oneYield 62%

Procedure

In a manner similar to that described in Example 1, dodecanoyl chloride (21.88 g, 0.1M) was treated with piperidine (8.52 g, 01M). Work up and distillation gave 16.55 g (62%) of the product, b.p. 185/2 mm.

Workup

distillationdistillation

Sources & evidence

ORD record: ord-9ae3a227ec2245e09984105f1463167f
Source dataset: uspto-grants-1989_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04837026

Reaction notes

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