3-(Benzyloxy)-1,2-dimethylpyridin-4(1H)-one → Deferiprone
Reaction equation
[CH3:1][N:2]1[CH:7]=[CH:6][C:5](=[O:8])[C:4]([O:9]CC2C=CC=CC=2)=[C:3]1[CH3:17]>Br>[CH3:1][N:2]1[CH:7]=[CH:6][C:5](=[O:8])[C:4]([OH:9])=[C:3]1[CH3:17]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
1,2-Dimethyl-3-benzyloxypyrid-4-one (2 g) is added to concentrated hydrobromic acid (10 ml) and heated in a steam bath for 30 minutes. The resulting mixture is then recrystallised from water to yield 1,2-dimethyl-3-hydroxypyrid-4-one (1 g), m.p. 230° C. (with decomposition); νmax (nujol) 1620, 3150 cm-1 ; δ(d6DMSO) 2.3(s, 3H), 3.8(s, 3H), 6.9(d, 1H), 7.8(d, 1H); M+ 139.
Workup
- temperatureheated in a steam bath for 30 minutes
- customThe resulting mixture is then recrystallised from water
Sources & evidence
- ORD record
- ord-40992e21567c4b20bcecab63b4454a51
- Source dataset
- uspto-grants-1989_06
- Patent number
- US04840958
Reaction notes
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