Pyridine → N-[3-(1H-benzimidazol-2-yl)-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide

HRID 190877

Reaction equation

HRID 190877 reaction equation
[C:48]([O:49][CH2:50][CH3:51])(=[O:52])[CH3:53].[CH2:54]1[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59]1.[CH3:34][S:35](=[O:36])(=[O:37])[c:38]1[c:39]([S:44](=[O:45])(=[O:46])[Cl:47])[cH:40][cH:41][cH:42][cH:43]1.[cH:28]1[cH:29][cH:30][n:31][cH:32][cH:33]1.[nH:1]1[c:2](-[c:10]2[n:11][n:12]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:25])([CH3:26])[CH3:27])[c:13]3[cH:14][cH:15][c:16]([NH2:19])[cH:17][c:18]23)[n:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2>>[n:1]1[c:2](-[c:10]2[n:11][n:12]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:25])([CH3:26])[CH3:27])[c:13]3[cH:14][cH:15][c:16]([NH:19][S:44]([c:39]4[c:38]([S:35]([CH3:34])(=[O:36])=[O:37])[cH:43][cH:42][cH:41][cH:40]4)(=[O:45])=[O:46])[cH:17][c:18]23)[nH:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2

Participants

6

Reactant 5

HCID 1049PyridineHCID 8078CyclohexaneHCID 8857Ethyl AcetateHCID 27351782-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 1363363453-(1H-benzimidazol-2-yl)-5-amino-1-{[2-(trimethylsilyl)ethoxy]methyl}indazole

Product 1

HCID 135621934N-[3-(1H-benzimidazol-2-yl)-1-(2-trimethylsilanylethoxymethyl)-1H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide

Sources & evidence

ORD record
ord-3becf322653e4110bdc7b0f9143d01d3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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