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Trimethylsilyldiazomethane → HCID 86657035, compound

HRID 1909138
Notes
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Reaction equation

HRID 1909138 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([CH3:13])=[CH2:12])[N:10]=1)[C:5]([OH:7])=[O:6].[N+](=[CH:16][Si](C)(C)C)=[N-]>ClCCl.CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([CH3:13])=[CH2:12])[N:10]=1)[C:5]([O:7][CH3:16])=[O:6]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 167693TrimethylsilyldiazomethaneHCID 86657036HCID 86657036, compound

Product 1

HCID 86657035HCID 86657035, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-chloro-6-isopropenylisonicotinic acid (0.25 g, 1.27 mmol) in dichloromethane (4.7 mL) and methanol (1.6 mL) was added (diazomethyl)(trimethyl)silane (0.63 mL, 1.27 mmol). After the addition, the mixture was concentrated and carried onto the next step. MS 212.0 (M+1).

Workup

  1. additionAfter the addition
  2. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-2d08f2d3334a4f7a87fc2643116b1aef
Source dataset
uspto-grants-2013_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08598209B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes