Tetrahydrofuran → 85633-52-9

HRID 1909775

Reaction equation

HRID 1909775 reaction equation
C([O:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.C1COCC1>[Pd].CCO>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([O:13][C:12]2[CH:20]=[CH:21][C:9]([OH:8])=[CH:10][CH:11]=2)[CH:15]=1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 689991853-(4-Benzyloxy-phenoxy)-pyridine

Product 1

HCID 1294063085633-52-9Yield 110.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The product from step 1 (130 mg, 0.469 mmol) was added to a vial containing THF (1 ml), EtOH (2.5 ml), 10% Pd/C (110 mg, 0.0469 mmol), charged with H2 and left to stir under H2 atmosphere overnight. The Pd/C was removed by filtering the reaction mixture through celite. The resulting solution was concentrated to give the title compound (97 mg, 100%).

Workup

  1. additioncharged with H2
  2. waitleft
  3. customThe Pd/C was removed
  4. filtrationby filtering the reaction mixture through celite
  5. concentrationThe resulting solution was concentrated

Sources & evidence

ORD record
ord-ec05e7af8dc64cb1a6250fa9ff0b6c07
Source dataset
uspto-grants-2013_12
Patent number
US08598359B2

Linked notes

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