1,4-Dioxane hydrochloride → 3,3-Difluoro-1,6-diazaspiro[3,4]octane
Reaction equation
C(OC([N:8]1[CH2:17][CH2:16][C:10]2([NH:13][CH2:12][C:11]2([F:15])[F:14])[CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1.Cl.CO>C(OCC)(=O)C>[F:14][C:11]1([F:15])[C:10]2([CH2:16][CH2:17][NH:8][CH2:9]2)[NH:13][CH2:12]1Participants
5
Procedure
To an optically-active compound of 3,3-difluoro-1,6-diazaspiro[3,4]octane-6-carboxylic acid tert-butyl ester (211 mg) were added 4M hydrochloric acid-1,4-dioxane (2.1 ml) and 2M hydrochloric acid-methanol (2.1 ml), and the mixture was stirred at room temperature for 45 minutes. To the reaction mixture was added ethyl acetate, and the mixture was filtered to give the titled compound (163 mg).
Workup
- filtrationthe mixture was filtered
Sources & evidence
- ORD record
- ord-942dc82627814c0095355308d8c14c86
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08609647B2
Reaction notes
Loading…