Methyl 4-Formylbenzoate → 4-(1-Hydroxy-2-methyl-propyl)-benzoic acid methyl ester

Reaction equation

[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[O:11])=[CH:6][CH:5]=1.[CH:13]([Mg]Cl)([CH3:15])[CH3:14]>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]([OH:11])[CH:13]([CH3:15])[CH3:14])=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 15294Methyl 4-Formylbenzoate

HCID 178418918HCID 178418918, compound

Product 1

HCID 595181984-(1-Hydroxy-2-methyl-propyl)-benzoic acid methyl ester

Procedure

This compound is made from 4-formyl-benzoic acid methyl ester and isopropylmagnesium chloride following the general method exemplified in Preparation 1.

Workup

customexemplified in Preparation 1

Sources & evidence

ORD record: ord-7a1be80588c1446eacab8d2a4c133621
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609892B2

Reaction notes

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