2-(4-Nitrophenyl)imidazo(1,2-a)pyridine → 4-(Imidazo(1,2-a)pyridin-2-yl)aniline
Reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]3[CH:18]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.C(OCC)(=O)C.[Ni]>[N:11]1[C:10]([C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)=[CH:18][N:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=12Participants
5
Reactant 1
Product 1
Reagents, catalysts & solvents 3
Procedure
4.50 g (18.8 mmol) 2-(4-Nitro-phenyl)-imidazo[1,2-a]pyridine and 0.45 g Raney-Nickel are stirred at RT under hydrogen (50 psi) in 50 mL ethanol and 50 mL ethyl acetate. The mixture is filtered and the solvent is evaporated.
Workup
- filtrationThe mixture is filtered
- customthe solvent is evaporated
Sources & evidence
- ORD record
- ord-05eb21efd5b940019ffc25c7d8f64c74
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08614238B2
Reaction notes
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