Hydrazine hydrate (1:1) → 4-iodo-5-methyl-1H-pyrazolo[3,4-b]pyridine
Reaction equation
F[C:2]1[C:7]([CH:8]=O)=[C:6]([I:10])[C:5]([CH3:11])=[CH:4][N:3]=1.O.[NH2:13][NH2:14]>O1CCOCC1>[I:10][C:6]1[C:5]([CH3:11])=[CH:4][N:3]=[C:2]2[NH:13][N:14]=[CH:8][C:7]=12Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-fluoro-4-iodo-5-methyl-pyridine-3-carbaldehyde (510 mg, 1.924 mmol) was dissolved in dry Dioxane (10 mL) and Hydrazine monohydrate (288.9 mg, 280.8 μL, 5.772 mmol) was added in one portion
Sources & evidence
- ORD record
- ord-0e3dba08173946638dd3ddb772ce9631
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08173635B2
Reaction notes
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