Hydrochloric Acid → 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one

Reaction equation

[N:1]1([C:7]2[C:16]3[O:15][C:14](=[O:17])[C:13]([NH:18]C(=O)C)=[CH:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl>>[NH2:18][C:13]1[C:14](=[O:17])[O:15][C:16]2[C:7]([N:1]3[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]3)=[CH:8][CH:9]=[CH:10][C:11]=2[CH:12]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 59427368N-[2-Oxo-8-(piperazin-1-yl)-2H-1-benzopyran-3-yl]acetamide

Product 1

HCID 111509643-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one

Procedure

Step 5 was the hydrolysis of the amide function of N-(8-(1-piperazinyl)-2-oxo-2H-1-benzopyran-3-yl-)acetamide (5*) using hydrochloric acid. This resulted in the trihydrochloric acid salt of 3-amino-8-(1-piperazinyl)-2H-1-benzopyran-2-one (6*).

Sources & evidence

ORD record: ord-e0da1c2fb6294ee08bb3181660657160
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173660B2

Reaction notes

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