Hydrochloric Acid → HCID 135995200, compound
Reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)[S:5][C:6]=1[CH3:7].Cl>O1CCOCC1>[CH3:1][C:2]1[N:3]=[C:4]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)[S:5][C:6]=1[CH3:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
(5-(4,5-dimethyl-1,3-thiazol-2-yl)-2,4-bis(methyloxy)pyrimidine) (Prep14, 118 mg, 0.470 mmol) in HCl (5.87 ml, 23.48 mmol) 4M in dioxane was stirred in a closed tube at 90° C. for 1.5 hour. Then the mixture was cooled to rt and the solvent evaporated under vacuum to afford the title compound as a pale grey solid (153 mg)
Workup
- customthe solvent evaporated under vacuum
Sources & evidence
- ORD record
- ord-5d8f4f088ea94406982bd822478c6c80
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08178549B2
Reaction notes
Loading…