Hydrochloric Acid → 5-(2-methyl-1,3-thiazol-4-yl)-2,4(1H,3H)-pyrimidinedione hydrochloride
Reaction equation
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[N:12]=[C:13]([CH3:16])[S:14][CH:15]=2)=[CH:5][N:4]=1.[ClH:17]>O1CCOCC1>[ClH:17].[CH3:16][C:13]1[S:14][CH:15]=[C:11]([C:6]2[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=2)[N:12]=1Participants
4
Procedure
2,4-bis(methyloxy)-5-(2-methyl-1,3-thiazol-4-yl)pyrimidine (Prep19, 290 mg, 1.222 mmol) was suspended in HCl 4M in 1,4-dioxane (10 ml). The reaction mixture was heated at 90° for 1 h and left at room temperature overnight. The solvent was then removed in vacuo to give the title compound as a solid (287 mg).
Workup
- temperatureThe reaction mixture was heated at 90° for 1 h
- customThe solvent was then removed in vacuo
Sources & evidence
- ORD record
- ord-88c614853412493e9dbabd86ffdb6fed
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08178549B2
Reaction notes
Loading…