Hydrazine hydrate (1:1) → 2-(6-Hydrazinylpyridin-3-yl)propan-2-ol
Reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.O.[NH2:13][NH2:14]>>[NH:13]([C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1)[NH2:14]Participants
3
Conditions
- Temperature
- 110 °C
Procedure
A mixture of 2-(6-chloropyridin-3-yl)propan-2-ol (975 mg, 5.68 mmol), and hydrazine hydrate (5512 μl, 114 mmol) was heated in a microwave on high absorbance for 10 hr at 110° C. The mixture was cooled to room temperature and the hydrazine was removed via rotary evaporation. The resulting yellow residue was used without further work-up.
Workup
- temperatureThe mixture was cooled to room temperature
- customthe hydrazine was removed via rotary evaporation
Sources & evidence
- ORD record
- ord-27ccae116e6240efa30b94b759b11845
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08178534B2
Reaction notes
Loading…